Targeting Mitochondria Degradation by Chimeric Autophagy-Tethering Compounds

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy

Mitochondria form close physical associations with the endoplasmic reticulum (ER) that regulate a number of physiological functions. One mechanism by which regions of ER are recruited to mitochondria involves binding of the ER protein VAPB to the mitochondrial protein PTPIP51, which act as scaffolds to tether the two organelles. Here, we show that the VAPB-PTPIP51 tethers regulate autophagy. We...

Targeting the Mitochondria by Novel Adamantane-Containing 1,4-Dihydropyridine Compounds

Targeting of Mitochondria-Endoplasmic Reticulum by Fluorescent Macrocyclic Compounds

BACKGROUND Useful probes of the intracellular environment that target a specific organelle in order to allow direct observation of the changes in these regions is of high current interest. Macrocyclic ligands have already revealed themselves as important selective hosts in some biological applications, forming stable and specific complexes. Therefore, in this paper, several macrocyclic ligands ...

EtBr-induced selective degradation of mitochondria occurs via autophagy.

Recent studies have implicated autophagy in numerous cellular responses to stress. During the establishment of human lung cancer cell lines without mitochondrial DNA, a significant depopulation of mitochondria occurred that was accompanied by the loss of the mitochondrial membrane potential. Notably, we observed autophagy in ethidium bromide (EtBr)-induced mitochondrial degradation. In the pres...

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson´s Disease

Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosomal degradative machinery, contributing to the formation of intracellular prote...